Secondary administration system



April 13, 1965 w. F. SALEM, JR., ETAL 3,177,870

SECONDARY ADMINISTRATION SYSTEM Filed Nov. 10, 1960 2 Sheets-Sheet 1 My?Q WM/ Q a A ril 13, 1965- w. F. SALEM, JR., ETAL 3,177,870

SECONDARY ADMINISTRATION. SYSTEM Filed Nov. 10. 1960 2 Sheets-Sheet 2v-\ 128 7 I 120 J29 INVENTORS.

29 H am 5L2? J22 M i 9 I may Mm L United States Patent ice 3,177,870SECGNDARY ADMINISTRATION SYTEIVI William F. Salem, In, Winnetka, andJames E. Alder, North Chicago, Ill., assignors to Abbott Laboratories,North Chicago, 11]., a corporation of Illinois Filed Nov. 10, 1960, Ser.No. 68,472 12 Claims. ((31. 128-214) This invention relates to a systemfor administering parenteral liquids. More particularly, this inventionrelates to an automatic valving system for parenteral administrationequipment adapted to operate within the confines of a liquid container.

In the course of administering a parenteral liquid, it is oftennecessary to administer along with the initial liquid, a second or evena third parenteral solution. To avoid making a separate insertion intothe body of the recipient for each such liquid, it is common practice toprovide some means of interconnecting the containers of each liquid intoa common feed line. This procedure requires the use of supplementaryequipment in addition to that usually provided with a standardparenteral solution container. When employing such additional equipment,constant supervision is required where it is desired to administer afirst solution and then to switch over to a second solution.

With the advent of the flexible plastic bag into the parenteralsolution-field, further problems were encountered. The plastic bag ismuch preferred over the standard bottle as it can be mass produced, ismore economical and is not fragile. However, the standard administrationequipment cannot, for obvious reasons, be attached to the flexiblewalled bag as it is to a bottle.

It is, therefore, an object of the present invention to provide avalving system for parenteral liquids which functions inside of a liquidcontainer and thereby eliminates the need of external supplementaryequipment.

It is another object of this invention to provide a valving system forparenteral liquids which will automatically deliver a first liquid andsubsequently a second liquid.

It is still another object of this invention to provide a valving systemfor plastic parenteral solution containers which affords secureattachment to the container with standard administration equipment.

It is also an object of this invention to provide a valve structurewhich has no parts projecting therefrom which must be manipulated toselect the desired parenteral liquid from two or more containersthereof, and which, therefore, does not involve the sealing problemsconnected with valve operators on conventional valves nor is there anypossibility of loss of sterility because of parts moving out of and intothe liquid containers.

Further objects of this invention are to provide a device foradministering parenteral liquids which employs a minimum number ofparts, is easily assembled and sterilized, and is disposable.

The foregoing objects and other objects of the present invention will bereadily appreciated by reference to the following detailed descriptionwhen considered in conjunction with the accompanying drawings showingembodiments of the invention wherein:

FIGURE 1 is an elevational view of two parenteral administration setsillustrating two embodiments of the present invention with each setbeing composed of two parenteral solution containers interconnected bymeans of a length of flexible tubing and one container of each sethaving a valve therein with another length of tubing leading therefromto a hypodermic needle.

FIGURE 2 is an enlarged fragmentary view of one of the solutioncontainers shown in FIGURE 1 with a portion broken away to betterillustrate one embodiment of a valve. a

FIGURE 3 is an enlarged view in vertical section of the valve of FIGURE2.

FIGURE 4 is a fragmentary view of a solution container that can beemployed in the administration sets of FIGURE 1 illustrating anotherembodiment of a valve therein.

FIGURE 5 is a View in vertical section of the valve of FIGURE 4.

FIGURE 6 is a fragmentary view of a solution container illustratingstill another embodiment of a valve to be used in the apparatus ofFIGURE 1, the valve being shown in vertical section.

FIGURE 7 is a view like FIGURE 6 illustrating yet another embodiment ofa valve.

FIGURE 8 is a view like FIGURE 6 illustrating still another embodimentof the present invention.

FIGURE 9 is a view in vertical section taken along line 9-9 of FIGURE 8.

Briefly stated, the apparatus of this invention is comprised of a firstor primary flexible, plastic, parenteral liquid container with a valvebody in the bottom of the container. The valve body has an openingcommunicating into the interior of the container. The valve body alsohas a discharge connection and a secondary fluid connection. Thedischarge connection is attached to a length of tubing leadingultimately to the recipient, and the secondary fluid connection isattached to a length of tubing which in turn is connected to a plasticcontainer containing a secondary parenteral liquid. In the valve bodyare means to block the flow of the primary liquid through the openinginto the valve body when the secondary liquid is flowing and permittingthe flow of primary liquid out through the discharge connection when thesecondary flow is stopped.

Proceeding to a detailed description, two embodiments of the presentinvention employing basically the same component parts, but differentvalving means, are shown in FIGURE 1. In one embodiment, generallyindicated at It), a first rectangular flexible container 11, composed ofa polyethylene material, has a valve body 12 located in the bottominterior thereof. Valve body 12 in this instance is molded from a highdensity polyethylene material.

Two lengths of flexible polyvinylchloride plasticized tubing 13 and 14are connected to valve body 12. Tubing 13 communicates with the interiorof a second polyethylene container 15 by means of a connector 16. In thepreferred embodiment, connector 16 actually is a valve body. With allthe containers having a valve body therein, any number of solutioncontainers may be connected in series and fluid selectively drawn fromany container. A sight or drip chamber 17 is attached to tubing 14 forindicating the flow rate. Chamber 17 in turn communicates withhypodermic needle 18 by means of tubing 19. Containers 11 and 15 aresupported at the same level by means of S-shaped hooks 22 and 23,respectively, which are attached to supporting arm 24 of standard 25.

As best illustrated in FIGURE 2, valve body 12 is placed inside anddiagonally across the bottom corner of container 11. The ends of tubing13 and 14 are secured to piercing pins 26 and 27, respectively. Twocircular flanges, 29 and 30 are provided on the respective pins. Thepreferred material for composing pins 26 and 27 is a methacrylate resin.

Valve body 12 is of a tubular configuration, and has an externalcylindrical wall portion 32 with a second internal wall portion 33 atone end thereof. Two oppositely disposed openings 34 and 35 are providedthrough wall 32. The internal diameter of wall portion 32 is of suchdimension as to frictionally receive pin 26 therein. Pin 26 has anannular shoulder 28 which frictionally engages the inner face of wallportion 32. Pin 27 telescopes within Patented Apr. 13, 1965 pin 26 withthe internal diameter of pin 26 being slightly larger than the externaldiameter of pin 27 thereby creating an axially aligned, capillary-likepassageway 36 between the tWo pins. Pin 26 has a reduced diametersection 37, and when inserted in valve body 12, creates a second axiallyaligned capillary-like passageway 38 between pin 26 and the inside ofvalve body 12.

Valve body 12 is tack sealed inside one corner of the container at thetime container 11 is formed and filled, for example, with isosaltsolution. -At the opposite corner of the container the two walls of thecontainer are sealed together'and an opening 31 provided through thesealed area to receive hook 22. Valve body 16, which is an exactduplication of valve body 12, is likewise sealed in container 15 with aparenteral solution such as dextrose. Containers 11 and 15 are thenready for shipment and storage.

When it is desired to administer the contents of containers 11 and 15they are supported at the corners opposite valve bodies 12 and 16 bymeans of hooks 22 and 23 respectively, which engage supporting arm 24. Astandard administration set having a sight chamber 17, a hypodermicneedle 18 and a tubing clamp 40, is employed with tubing 14 beingconnected to piercing pin 27. With clamp 40 in the closed position ontubing 14, pin 27 is inserted through wall 39 of container 11 and intovalve body 12 within interior wall 33. Wall 33 with pin 27 placedtherein serves to seal oft the end of valve body 12. A length of tubing13 having piercing pin 26 connected thereto at one end and a second pin(not shown but of the same structure as represented by numeral 27) isemployed to interconnect containers 11 and 15. Pin 26 is inserted invalve body 12 and around pin 27. With clamp 42 in the closed position,the second pin at the opposite end is connected to valve body 16 in thesame manner as pin 27 engages valve body 12. Upon insertion of needle 18into the vein of recipient, the apparatus is ready for operation.

In this instance, it is assumed that the dextrose solution in containeris to be administered first and the isosalt solution in container 11,second. Clamps 40 and 42 are opened and the dextrose solution flowsthrough valve body 16, into tubing 13 and into a small portion ofchannel 43 of pin 26 where it flows into channel 44 of pin 27 and oninto tubing 14 to the recipient. While the dex trose solution is takingthe previously describedcourse, the isosalt solution in container 11 hastraveled through openings 34 and 35 of valve body 12 and intopassageways 38 and 36. However, the rate of flow of isosalt solution isimpeded by the small cross sectional area andthe length of capillarypassageways 36 and 38. This frictional drag when coupled with the headpressure of the dextrose solution prevents the isosalt solution fromentering the channel 43. When all the dextrose solution has passed fromcontainer 15,. or the fiow is interrupted by closing clamp 42, isosaltsolution from container 11 will enter channels 43 and 44 and throughtubing 14 to the recipient. It will be noted that tubing 13 is allowedto drop below valve bodies 12 and 16. This serves as a trap for thedextrose solution and prevents isosalt solution from leaking into tubing13 when the flow of the dextrose solution is stopped either by closingclamp 42 or by the emptying of container 15.

The capillary-like passageways 36 and 38 prevent any flow from container11 so long as liquid is flowing from container 15. At the same time, thechannels prevent any of the solution from container 15 from flowing backinto container 11 even though there may be a substantial difference inspecific gravity or density of the two liquids in the containers. Thus,valve body 12, along with the two pins 26 and 27, acts as a valve whichis controlled by controlling the flow of fluid from container 15 throughthemanipulation of clamp 42.

The specific valve structure wherein capillary-like channels areemployed to control the flow and prevent mixing is the invention ofRichard W. Pecina, Frank C. Dayton, Jr. and Henry M. Scislowicz. It isthe subject matter of a patent application filed March 29, 1961, SerialNo. 99,083, now abandoned. However, since such a valve mayadvantageously be used in connection with our invention, it has beenillustrated and described herein.

Another embodiment, generally 50, of the presentinvention is shown inFIGURE 1 and is similar in its component parts to that of device 19.Embodiment has a plastic blood container 51, a secondary plasticcontainer 52 for parenteral solutions such as dextrose and aninterconnecting length of flexible tubing 59. A valve body 54, which isan exact duplicate of valve body 12, is provided in the bottom corner ofcontainer 52 and is connected to tubing 59 in the manner described inreference to valve body 12. A valve body 55 also is placed in the bottomcorner of container 51. Tubing 59 communicates with valve body 55 andhas clamp 56 engaged thereon- Another length of tubing. 57 communicateswith valve body 55 and is connected to a hypodermic needle or deliverymember 58. The standard drip chamber. as repre sented by numeral 17 canbe attached to tubing 57 in the usual manner. Container 52 is supportedby S shaped hook 60 engaging arm 24 and container 51 is supported byhook 61 engaging arm 62.

Referring specifically toFIGURE 7, there is shown a valve generallyindicated, at 55 having a valve body 55a. The valve body 55a has acurved tubular body 63 with an open-ended marginal inlet end 64 and anopen-ended marginal outlet end 65 for frictionally accommodatingcannulae 66 and 67 having piercing ends or fitments 66a and 67a,respectively, therein. The marginal inlet and outlet ends 64 and 65 inthe valve body 55a extend beyond openings 68 and 69, respectively. Anopening 70 defining a valve seat 70a is provided in the valve body 55a.A metal valving ball 71 of a slightly smaller diameter than passagewayor chamber 72 is housed therein. It will be seen that the valve body 55ahas two ends 73 and 74 that extend upwardly in the container 51. Theends 73 and 74 surround the openings 70 and 68, respectively, and definevalve seats with which the ball 71 cooperates to shut 011 the fluid flowas hereinafter described. The preferred material for composing the valvebody 55a is a plasticized polyvinylchloride material. Valve bodies 54and 55a are placed in the containers 52 and 51, respectively, in themanner generally described for the containers 11 and 15.

The contents of the containers 51 and 52 are administered in a mannersimilarly described for the containers 11 and 15 except that thecontainer 52 is placed at a higher level than container 51. The cannulae66 and 67 to which the tubing 59 and 57, respectively, are connected,are inserted through the walls of the container 51 and seated in themarginal inlet and outlet ends 64 and 65. The tubing 59 is connected tothe container 52 in thesame manner as the tubing 13 was connected to thecontainer 15. When the clamp 56 is opened, the dextrose solution incontainer 52 flows through tubing 59 and into passageway 72 by way ofopening 68. This forces the ball 71 against the valve seat 70aobstructing the opening 70 and preventing the blood from the container51 from entering the passageway or chamber 72 and flowing into thetubing 57.' The obstruction of the opening 70 also prevents the dextrosefrom mixing with the blood in the container 51. The purpose for havingthe container 52 at an elevated height is to give the dextrose solutionflowing against the ball 71 a greater head pressure than the blood whichtends to flow through the opening 70. When all of the dextrose solutionhas passed from the container 52, the pressure of the blood will forcethe ball 71 away from the opening 70 and against the opening 68 therebypermitting the blood to flow into the tubing 57 and to the recipient. Ifthe clamp 56 is closed, the same result occurs, but in addition, thepresence of the ball 71' over the opening 68 obstructs that opening andprevents the blood from mixing with the dextrose in the tubing 59.

A further embodiment of a valve generally indicated at 80 is illustratedin FIGURES 4 and 5 for use in flexible plastic container 81. A valvebody 80' is of a generally cylindrical configuration with a truncatedconical bottom portion. It is formed from high density polyethylenematerial. The valve body 80' has a top 82 with an opening 84 forcommunication with a closed, internal chamber 83 of the valve body 80'.A flexible flap 85 of the same material as the valve body 841' issecured to the inside of top 82 by means of projection 86 and is biasedby the secondary liquid so as to normally be urged in a position tocover the bottom of the opening 84. A piercing cannula having a piercingend 87a secured to tubing 88 communicates with the chamber 83 of valvebody 80 through an accommodating opening 80:: in tapering side wall 89formed by the truncated conical portion of valve body 80'. The cannula87 frictionally engages the valve body 80'.

The valve body 80 is sealed in the container 81 and the container filledwith the desired parenteral solution in the manner previously describedfor the other embodiments. As shown in FIGURE 4, the valve body 80' canbe substituted in the device 50 for the valve body 54 in the container52. In this form, the valve body 80 serves as a means of securing thecannula 87 in the con tainer 81. The tubing 88, connected to cannula 87,leads to a hypodermic needle in the recipient.

The valve body 80' has a second opening 80b to receive a second piercingcannula 90 having a piercing end 90a which frictionally engages valvebody 80. With the second piercing cannula 90 connected to the tubing 91and communicating with the interior of the valve body 80, as shown inFIGURE 5, the container 81 andthe valve body 81) can be substituted forthe valve body 55 in the container 51. In this case, the tubing 91 isconnected to the container 52 in place of the tubing 59. When thecontainer 81 contains isosalt and the tubing 91 is connected to asecondary source of parenteral solution such as dextrose, the dextrosesolution will flow into valve body 30' through tubing 91. The headpressure will force the flap 85 against the opening 84 and therebyprevent isosalt from flowing into the chamber 83. The dextrose solutionflows from the chamber 83 to the re cipient through the tubing 88. Ifthe flow from the tubing 91 is cut off, as by means of a tubing clamp,the liquid in the container 81 will force the flap 85 away from opening84 and will flow out through tubing 88. In all other respects, thefunction of the container 81 and the valve body 80'vis the same as thatdescribed generally for device 50. i

In all instances, the delivery of parenteral liquid to the recipient isextremely slow, that is, the liquid flow through the sight chamberbetween the last container in the series and the needle is only a dropat atime. For example, in FIGURE 1, the tubing clamp 40 is adjusted sothat the flow of liquid into the sight chamber 17 is seen as individualdrops. Thus, the tubing clamp 40 so obstructs the tubing 14 that thereis a back pressure in the interior of the valve body 12. Similarly, inthe use of the embodiment of FIGURE 5, there is a back pressure in thechamber 83, because of the constriction pro- 'vided by a tubing clamp onthe like downstream there from, i.e., between the chamber 83 and thehypodermic needle.

FIGURE 6 illustrates a float type valve 101 which is composed of thesame materials as the valve 80 of FIG- URES 4 and 5, namely, a highdensity polyethylene plastic. It is fabricated and operated in the samemanner. A container 100 encloses a hollow valve body 101:: which definesa chamber 101]; which is of a truncated conical configuration, having atapered opening 102 defining a valve seat 102a in the center of the top103 thereof. A float 104 is housed in the valve body 101a and has aguide 105 and a tapering plug member 106 for reception in the opening102. The guide 105 is of sufiicient length to maintain contact with theopening 1132 at all times. Lateral, angular fins 108 are provided forthe float member 104 and serve to allow liquid to flow about the floatbetween the top and bottom of the chamber 101i). The fins 108 also serveas a limiting stop means to restrict the downward movement of the float.Liquid in the container 100 thereby flows through the opening 102, alongthe fins 108, through a cannula 110 and out the tubing 112. The cannula110 having a piercing end 110a is inserted through the wall of thecontainer 100 and into anopening 109 in valve body 101, in which the pinis frictionally engaged. The tubing 112 leads to a hypodermic needleinserted in the recipient. The valve body 101a has a third opening 113therein. If two liquids, in two containers, are to be connected to asingle hypodermic needle, a second cannula 114 having a piercing end114a is inserted through the wall of container 100 and into opening 113where the cannula 114 is frictionally engaged by the valve body 101a. Alength of tubing 115 is connected to a second container corresponding tocontainers 15 or 52. If liquid is permitted to flow through the lengthof tubing 115 that liquid will fill the chamber 101b sufliciently fullto raise the float 104 and seat the plug member 106 in the valve seatdefined by the opening 102, thereby obstructing the flow of liquid fromthe container 100. The normal rate of flow to the recipient through thetubing 112 is so slow (as previously mentioned with respect to FIGURE5), that there is no problem of the chamber 107 not filling. Of course,the second liquid from tubing 115 also will flow to the recipientthrough tubing 112. When the flow of liquid through the tubing 115 isobstructed, the float 104 again will descend and permit the liquid fromthe container 100 to flow to the tubing 112. 7

A substantially fiat walled V-shaped valve body is shown in FIGURE 8 inconjunction with container 121. Valve body 120 like the previouslydescribed valve body of FIGURE 5 is composed of a high densitypolyethylene material. A T-shaped passageway 122 is provided in valvebody 120 with piercing pins 124 and 125 being frictionally engaged inthe tubular arm portions 126 of passageway 122. Pins 124 and 125 areconnected to lengths of flexible tubing 127 and 128, respectively.Container 121 with valve body 120 canbe used in place of valve body 12in container 11, or it can be used in conjunction with anelevatedcontainer as shown in device 50. Valve body 120 operates on the sameprinciple as valve body 12. To illustrate, a secondary liquid flows inthrough tubing 127, through the tubular portion, between the pins intopin 125 and out through tubing 128.

The primary liquid'in container 121 tends to flow through the narrowpassage 12!! of passage 122 which is in open communication with theinterior of container 121. However, because of the narrow thickness ofpassage 129 (as illustrated in FIGURE 9), the flow of the primary liquidis impeded. This frictional resistance when coupled With the headpressure of the secondary liquid passing through the arm portion 126halts the flow of the primary liquid into either tubing 127 or 128. Thisfrictional resistance in narrow passage 129 also prevents the secondaryliquid from entering the primary liquid container 121. When the flow ofsecondary liquid from tubing 127 is stopped, the primary liquid fromcontainer 121 will flow through passage 129 and into tubing 128. Flow"of secondary liquid from the tubing 127 may be stopped by a tubingclamp closing the tubing or by the emptying of the container holding thesecondary liquid.

The plastic containers 11, 15, 51, 52, 81, 100 and 121 have beendescribed as being composed of a polyethylene material. It should beunderstood that other plastic materials such as polypropylene,plasticized polyvinylchloride and polyvinylidene-chloride, commonly 'outthe supervision of an attendant. "ondary liquid permitted to flow, itwill cut ofl flow of known as Saran, could also be employed. As regardsthe valve body, in addition to high density polyethylene,

posed of any rigid material such as nylon, polyethylene andpolypropylene. While the novel apparatus of the present invention hasbeen shown for use with two liquid containers, it should be understoodthat three or more plastic solution bags, could be interconnected in aseries as suggested by FIGURE 1. By closing the tubing, (as by means ofa tubing clamp 42), just beyond the container holding the liquid to bedelivered to the needle (e.g. 18), the valve in that container willallow the liquid to flow from the container. The liquid flowing fromthat container through the valves of all containers downstream therefromwill prevent any liquid from flowing out of those downstream containers.7

The term parenteral liquid has been used interchangeably herein withdextrose, isosalt solutions and blood. It should be understood that itis meant to include all the commonly known liquids which are fed by theintravenous 'route such as Aminosol, Ringers solution, the variousisotonic solutions and the like.

It will be seen that applicant has provided a valving systemforparenteral liquids which functions within the confines of aparenteral liquid container and can also be made integral with thecontainer. When the valving mechanism is employed to adminster a primaryand a secondary parenteral liquid, it can do so automatically with- Thatis, if the secthe primary liquid. Upon the emptying of the containerholding the secondary liquid, the primary liquid flow will automaticallybe established. When it is desired to administer only a single liquid,the valving mechanism serves as a means of attaching a piercing pin forcommunication with the inside of a plastic solution bag. All of thevalve bodies utilized in the present invention are molded from a plasticmaterial and employ a minimum of parts. This results in a substantialcost savings and trouble free operation.

The terms primary and secondary have been used herein with respect tothe liquids in the containers for identification purposes only and notas necessarily being indicative of the order of their importance orsequence of delivery to the recipient. These latter factors Will bedetermined by the doctor, etc., supervising the administration ofparenteral liquids to the recipient. In some instances, two or morecontainers each holding the same liquid would be connected together aspreviously described. In

'such case, the extra containers would act as a reserve supply for thecontainer from which liquid was being delivered. When the lattercontainer is emptied, the next container in the series automaticallywould commence delivering the liquid.

Others can readily adapt the invention for use under .various conditionsof service, by employing one or more of the novel features disclosed orequivalents thereof. As at present advised with respect to the scope ofour invention, there is claimed the following subject matter. What isclaimed is: p 7 l. A parenteral administration apparatus con'rprising afirst source of parenteral fluid, a second source of parenteral fluid, avalve body located in said first source of parenteral fluid defining aflow chamber, a deliverymember in communication with said chamber,conduit means intercommunicating said chamber and said second source offluid, passage means intercornrnunicating said chamber and said firstsource of fluid and means in said chamber to block and unblockcommunication between said chamber and said first source of fluidresponsive respectively to flow and cessation of flow from said secondsource of fluid to said chamber.

first container containing a first parenteral fluid, a second containercontaining a second parenteral fluid, a valve body located in said firstcontainer defining a flow chamber, a delivery member, first conduitmeans intercomrnunicating said delivery member and said chamber, secondconduit means intercommunicating said chamber and said second container,passage means intercommunicating said chamber and said first containerand means operative to interrupt and permit communication between saidchamber and said first container responsive respectively to fluid flowand cessation of flow from said second container to said chamber.

3. A parenteral administration apparatus comprising a first source ofparenteral fluid, a second source of parenteral fluid, a hypodermicneedle, a valve body located in said first source of parenteral fluidand defining a flow ond plastic bag containing a second parenteralfluid, a

valve body located in said first plastic bag, a flow chamber defined bysaid valve body, a port defined by said valve body intercommunicat-ingsaid chamber and said first fluid, first conduit meansintercommunicating said chamber and said second plastic bag, a deliverymember, second conduit means intercornmunicating said chamber and saiddelivery member, and means in said chamber to respectively close andopen said port responsive to flow and cessation of flow of said secondparenteral fluid into said chamber.

- ery means, first conduit means intercommunicating said first cannulaand said delivery means, a second cannula extending through said firstbag in communication with said chamber, second conduit meansintercommunicating said second cannula and said second bag, a portdefined by said valve body communicating said chamber with said firstfluid, and means located in said chamber to respectively block andunblock said port in response to flow and cessation of flow of saidsecond parenteral fluid into said chamber.

' 6. Apparatus as claimed in claim 5 wherein said lastnamed meanscomprises a ball seatable over said port.

7. Apparatus as claimed in claim 5 wherein said lastnamed meanscomprises a flexible flap having a first end face attached to said valvebody and a second end face seatable over said port.

8. Apparatus as set forth in claim 5 wherein said last- -named meanscomprises a float member having a plug attached to said float andseatable over said port.

9. A parenteral administration apparatus comprising a ;first plastic bagcontaining a first parenteral fluid, a secin one of said apertures incommunication with said chamber, a first conduit intcrcommunicating saidsecond bag and one of said cannulae, a deilvery member, a second conduitintercommunicating said delivery member and the other of said cannulae,and means located in said chamber to respectively block and unblock saidport in response to flow and cessation of fiow of said second parenteralfluid into said chamber.

10. Apparatus as set forth in claim 9 wherein said port is located inthe top of said valve body and wherein said last-named means comprises aflexible flap having a first end face secured to the valve body and asecond end face seatable over said port.

11. Apparatus as set forth in claim 9 wherein said port is located inthe top of said valve body and wherein said last-named means comprises afloat member and a plug member overlying said float and seatable oversaid port.

12. A parenteral administration apparatus comprising a first plastic bagcontaining a first parenteral fluid, a second plastic bag containing asecond parenteral fluid, a tubular valve body located in said first bagand having an upturned end portion, a flow chamber defined by said valvebody, a pair of fitments attached to said valve body and communicatingwith said chamber, a pair of cannulae, each of said cannulae extendingthrough said first bag and respectively sealingly seated in one of saidfitments, a first conduit intercommunicating one of said cannulae andsaid second bag, a delivery member, a second conduit i0intercommunicating said delivery member and the other of said cannulae,a port defined by said upturned end portion of said valve body and aball located in said chamber and adapted to seat over said port inresponse to ficw of said second parenteral fluid into said chamber.

References (Iited by the Examiner UNITED STATES PATENTS 728,782 5/03Tate et al. 251-127 2,584,877 2/52 Hoffman et a1 137-1 19 2,989,973 6/61Prather l37-l l3 FOREIGN PATENTS 204,174 7/59 Austria.

1,042,837 11/58 Germany. 1,082,035 6/54 France.

OTHER REFERENCES Klein et al.: Simple Methods for the Aseptic Separationof Blood Components, Bibleotheca Haematologica (Basel), vol. 7, Jan. 20,1958, pp. 382-385.

RICHARD A. GAUDET, Primary Examiner.

ROBERT E. MORGAN, JORDAN FRANKLIN,

Examiners.

1. A PARENTERAL ADMINISTRATION APPARATUS COMPRISING A FIRST SOURCE OFPARENTERAL FLUID, A SECOND SOURCE OF PARENTERAL FLUID, A VALVE BODYLOCATED IN SAID FIRST SOURCE OF PARENTERAL FLUID DEFINING A FLOWCHAMBER, A DELIVERY MEMBER IN COMMUNICATION WITH SAID CHAMBER, CONDUITMEANS INTERCOMMUNICATING SAID CHAMBER AND SAID SECOND SOURCE OF FLUID,PASSAGE MEANS INTERCOMMUNICATING SAID CHAMBER AND SAID FIRST SOURCE OFFLUID AND MEANS IN SAID CHAMBER TO BLOCK AND UNBLOCK COMMUNICATIONBETWEEN SAID CHAMBER AND SAID FIRST SOURCE OF FLUID RESPONSIVERESPECTIVELY TO FLOW AND CESSATION OF FLOW FROM SAID SECOND SOURCE OFFLUID TO SAID CHAMBER.